麻酔科・ペインクリニック科

麻酔・ペインクリニックに関する論文や著書は多数あり，指導下に医局員が研究成果を継続的に多数発表している。とくに全身麻酔時の神経筋モニタリングを用いた筋弛緩薬および筋弛緩拮抗薬の安全な投与法を本邦に普及させ，患者安全向上に寄与してきた功績は大きい。Nippon Neuromuscular Meeting 第１回，第2回研究奨励賞等を受賞。

• Takagi S, Kitajima O, Yamamoto M, Matsui M, Suzuki T. Potentiation by sevoflurane of rocuronium-induced neuromuscular block is greater in older than younger adult patients: a randomised controlled trial. Br J Anaesth. 2020;125(4):e351-e3.
• Takagi S, Sugaya N, Kiuchi N, Iwasa A, Itagaki M, Seki A, et al. High-dose rocuronium-induced paralysis of the adductor pollicis muscle facilitates detection of the timing for tracheal intubation in elderly patients: a randomized double-blind study. J Anesth. 2020;34(6):876-80.
• Takagi S, Kijima M, Iwasaki H, Doshu-Kajiura A, Kitajima O, Suzuki T. Extravascular leakage of induction doses of rocuronium: four cases in which both depth of neuromuscular block and plasma concentration of rocuronium were assessed. J Clin Monit Comput. 2021.
• Higuchi H, Takagi S, Onuki E, Fujita N, Ozaki M. Distribution of epidural saline upon injection and the epidural volume effect in pregnant women. Anesthesiology. 2011;114(5):1155-61.
• Higuchi H, Takagi S, Zhang K, Furui I, Ozaki M. Effect of lateral tilt angle on the volume of the abdominal aorta and inferior vena cava in pregnant and nonpregnant women determined by magnetic resonance imaging. Anesthesiology. 2015;122(2):286-93.

• 北島治、鈴木孝浩、深野直子、三宅絵里、佐伯　茂、小川節郎
  ネオスチグミンによる神経筋刺激伝達抑制に関する検討
  麻酔   58(4)： 410-415, 2009 　　
• Osamu Kitajima, Takahiro Suzuki, Naoto Watanabe, Takeshi Maeda, Yoshikazu Noda, Shigeru Saeki, Setsuro Ogawa
  Monitoring masseter muscle evoked responses enables faster tracheal intubation
  Journal of Anesthesia  24(2): 173–176, 2010
• Kitajima O, Suzuki T, Fukano N, Saeki S, Ogawa S, Noda Y 
  Onset of rocuronium-induced neuromuscular block evaluated subjectively and accerelomyographically at the masseter muscle.
  Journal of Anesthesia  25(3): 376-379, 2011 
• Osamu Kitajima, Mai Yamamoto,  Shunichi Takagi,  Takahiro Suzuki. Potency estimation of sugammadex for the reversal of moderate rocuronium‐induced neuromuscular block: a non‐randomized dose–response study. 
  Journal of Anesthesia  34(3):348–351, 2020

• Insertion/deletion polymorphism of the angiotensin converting-enzyme considerably changes postoperative outcome; Journal of Clinical Anesthesia, 2012 Dec;24(8):631-8.
• Hyperinsulinemic Normoglycemia during Cardiac Surgery Reduces a Composite of 30-day Mortality and Serious In-hospital Complications: A Randomized Clinical Trial Anesthesiology. Published online March 13, 2018. Anesthesiology 128(6),pp.1125-1139.2018.
• Parenteral amino acid supplementation with high dose insulin prevents hypoaminoacidemia during cardiac surgery. Nutrition 69,pp.110566.2020.
• Safety and efficacy of the percutaneous thoracis endvascular repair with regional anesthesia. General Thoracic and Cardiovascular Surgery. 69(2),pp.267-273.
• Minimum-incision trans-subclavian transcatheter aortic valve replacement with regional anesthesia. Journal of cardiology. S0914-5087((22)),pp.00169-1.
• 末梢神経ブロックハンズオン120%活用術-RA Asiaのチャンスを見逃すな<後編>ハンズオン受講者の予習と準備（英語編）, LiSA, p461-466, (株)メディカル・サイエンス・インターナショナル,東京，2018年４月号
• 【別冊秋号・周術期管理】(PART2)術前合併症アップデート心疾患, LiSA, pp115-124 ,(株)メディカル・サイエンス・インターナショナル,東京，2020年９月号
• 「症例カンファレンス」心機能が極度に低下した透析患者に対する大腿切断術, LiSA, p1113-1116 ,(株)メディカル・サイエンス・インターナショナル,東京，2020年11月号
• OPA 超音波ガイド下神経ブロック技術向上にブロック針ガイドは有効か？, 麻酔科プラクティス４ スキルアップのための麻酔科臨床解剖, p78-83 ,文光堂,東京，2022年５月
• 症例カンファレンス」透析患者のTAVI, LiSA, p1-17 ,(株)メディカル・サイエンス・インターナショナル,東京，2022年1月号
• 区域麻酔厳選100問, (株)メディカル・サイエンス・インターナショナル,東京，2023年1月
• こだわる！神経ブロック上肢, 中外医学社,東京，2023年５月

• Doshu-Kajiura A, Suzuki J, Suzuki T. Prolonged onset and duration of action of rocuronium after accidental subcutaneous injection in a patient with chronic renal failure-a case report. JA Clin Rep 2021; 7:18
• Kajiura A, Kinoshita H, Otake K, Yamasaki T. Perioperative thyroid function in a　patient with angina pectoris coexisting with Graves' disease undergoing coronary artery bypass grafting. J Cardiothorac Vasc Anesth 2019; 33: 3528-9
• Kajiura A, Nagata O, Sanui M. The Pringle maneuver reduces the infusion rate of rocuronium required to maintain surgical muscle relaxation during hepatectomy. J Anesth 2018; 32: 409-13
• Kajiura A, Nagata O, Takizawa Y, Nakatomi T, Kodera S, Murayama T. A large individual variation in both the infusion rate, and the blood concentration of rocuronium necessary for obtain adequate surgical muscle relaxation during total intravenous anesthesia with propofol and remifentanil. J Anesth 2015; 29: 9-14

• Mirogabalin improves cancer-associated pain but increases the risk of malignancy in mice with pancreatic cancerPain. 2023; 164: 1545-1554

• Oshima Y, Seino Y, Takagi S, Kiuchi N, Nomura T, Suzuki T : The Utility of Point-of-Care Transesophageal Echocardiography in the Intensive Care Unit for Detecting the Cause of Hemolytic Anemia After Ascending Aorta Replacement. J.jvca. (in press, published online : October 05, 2020)

• Midazolam exhibits antitumour and anti-inflammatory effects in a mouse model of pancreatic ductal adenocarcinoma. Br J Anaesth.